Comparison of Methylation Density In Different Cancer Types By HumanMethylation450 Methods

Abnormal hypermethylation of DNA is highly detected in many cancer types. It is accepted that the hypermethylation contributes to tumor developing by silencing the tumor suppressor genes expression. New data techniques, Illumina Infinium HumanMethylation450, gives us a wide approach about genome methylation density and location. 8 different TCGA cancer data were compared. As a result, hypomethylated and hypermethylated genes were selected. Moreover, the highest methylated chromosomes, such as 19, 16, 17, 7, 11, 1, have been detected among the cancer types. The lowest and the highest beta value of the genes and chromosomes may give us a methylation range to understand future methylation process. Physical map of hypermethylated, near the both ends of chromosomes, and hypomethylated genes, near the centromere, is another result of this paper.